期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 133, 期 1, 页码 53-59出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbiopara.2003.09.002
关键词
Plasmodium; malaria; salivary glands; circumsporozoite protein; mosquito; sporozoite
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI044470, R01AI056840] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI44470, R01 AI044470-03, R01 AI044470, R01 AI044470-04, R01 AI056840] Funding Source: Medline
Plasmodium sporozoites develop in oocysts on the midgut wall of the mosquito and are released into the hemocoel. Approximately 15-20% of oocyst sporozoites will successfully attach to and invade salivary glands, their target organ. We have previously shown that the major surface protein of sporozoites, the circumsporozoite (CS) protein, binds specifically to salivary glands and not to other mosquito organs exposed to circulating hemolymph. In addition, a peptide from the N-terminal portion of CS protein inhibits binding of the protein to the glands. In this study, we have extended these findings and show that both the protein and the peptide can inhibit sporozoite invasion of salivary glands. (C) 2003 Elsevier B.V. All rights reserved.
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