期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 27, 期 1, 页码 57-60出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/BF02980047
关键词
18 beta-glycyrrhetinic acid-3-O-beta-D-glucuronide; glycyrrhizin; streptococcus LJ-22; anti-allergic activity
Glycyrrhizin (18beta-glycyrrhetinic acid-3-O-beta-D-glucuronopyranosyl-(1-->2)-beta-D-glucuroniae, GL) was transformed to 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide (GAMG) by Streptococcus LJ-22. The antiallergic activities of GL and GAMG was measured using a RBL cell assay system and contact hypersensitivity model mice. GAMG exhibited anti-allergic activity with IC50 values of 0.28 mM. GAMG, which is sweeter than GL, and 18beta-glycyrrhetinic acid, which is a GAMG metabolite by human intestinal bacteria, also inhibited the passive cutaneous anaphylaxis and skin contact inflammation. In conclusion, GAMG may be useful as a new sweet food additive and an anti-allergic agent.
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