期刊
ARTHRITIS RESEARCH & THERAPY
卷 6, 期 5, 页码 197-202出版社
BIOMED CENTRAL LTD
DOI: 10.1186/ar1222
关键词
autoimmune diseases; B cells; BAFF (BLyS); co-stimulation; therapy
类别
资金
- NIAID NIH HHS [AI31229, R01 AI047291, AI47291] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P01AI031229, R01AI047291] Funding Source: NIH RePORTER
It is increasingly recognized that B cells have multiple functions that contribute to the pathogenesis of autoimmunity. Specific targeting of B cells might therefore be an appropriate therapeutic intervention. The tumor necrosis factor-like molecule BAFF (BLyS) is a key B cell survival factor and its receptors are expressed on most peripheral B cells. Several different BAFF antagonists are under development and in early clinical trials. We review here the rationale for BAFF blockade, and its predicted mechanism of action in autoimmune diseases.
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