期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 53, 期 9, 页码 1043-1070出版社
SAGE PUBLICATIONS LTD
DOI: 10.1369/jhc.5R6647.2005
关键词
basophil; mast cell; ultrastructure; secretion; vesicle transport; piecemeal degranulation; recovery from degranulation; synthesis; granules; lipid bodies
类别
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI033372] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI-33372] Funding Source: Medline
Ultrastructural studies of human mast cells (HMCs) and basophils (HBs) are reviewed. Sources of HMCs include biopsies of tissue sites and in situ study of excised diseased organs; isolated, partially purified samples from excised organs; and growth-factor-stimulated mast cells that develop de novo in cultures of cord blood cells. Sources of HBs for study include partially purified peripheral blood basophils, basophils in tissue biopsies, and specific growth factor-stimulated basophils arising de novo from cord blood cells. The ultrastructural studies reviewed deal with identity, secretion, vesicles, recovery, and synthesis issues related to the biology of these similar cells.
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