期刊
NATURE REVIEWS IMMUNOLOGY
卷 5, 期 9, 页码 722-735出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1686
关键词
-
类别
资金
- Wellcome Trust Funding Source: Medline
Malaria is possibly the most serious infectious disease of humans, infecting 5 - 10% of the world's population, with 300 - 600 million clinical cases and more than 2 million deaths annually. Adaptive immune responses in the host limit the clinical impact of infection and provide partial, but incomplete, protection against pathogen replication; however, these complex immunological reactions can contribute to disease and fatalities. So, appropriate regulation of immune responses to malaria lies at the heart of the host - parasite balance and has consequences for global public health. This Review article addresses the innate and adaptive immune mechanisms elicited during malaria that either cause or prevent disease and fatalities, and it considers the implications for vaccine design.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据