期刊
EPILEPSY & BEHAVIOR
卷 7, 期 2, 页码 214-221出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2005.05.021
关键词
peltier device; thermoelectric; seizure detection; cooling; hypothermia; focal epilepsy; heat pipe
资金
- NINDS NIH HHS [R21 NS045652, R01 NS42936, P01 NS32636] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS042936, R21NS045652, P01NS032636] Funding Source: NIH RePORTER
The therapy of focal epilepsy remains inadequate. Many patients who have localization-related seizures find themselves either overmedicated with anticonvulsants or suffering from frequent seizures. While surgical resection can lead to excellent outcomes in up to 60% of patients with neocortical epilepsy, there are obviously many who either fail surgery or are deemed inappropriate surgical candidates. We are currently determining the efficacy of local cooling for the therapy of certain focal epilepsies. We have attempted to adapt new technologies borrowed from electrical and mechanical engineering to develop cooling devices that will ultimately improve the diagnosis and therapy of these focal epilepsies. The present review describes the rationale for this research and our progress to date. (c) 2005 Elsevier Inc. All rights reserved.
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