期刊
LUPUS
卷 14, 期 1, 页码 13-18出版社
ARNOLD, HODDER HEADLINE PLC
DOI: 10.1191/0961203305lu2053oa
关键词
fibrosis; glomerulonephritis; inflammation; lupus; renal cytokines
类别
Although far from complete, the picture of cytokines present in systemic lupus erythematosus (SLE) glomerulonephritis is already complex. Proinflammatory cytokines, such as TNF, IL-6, IL-1, and IL-18 are upregulated, as are both Th1 and Th2 cytokines, with different implications. In many instances, the local effects may be different from the systemic immunoregulatory ones. For some proinflammatory cytokines, and TNF in particular, the local proinflammatory ones may be more relevant to the disease. This may help solve discrepancies between different murine models of the disease and provide a better rationale for targeting certain cytokines in human SLE.
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