期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 6, 期 1, 页码 32-43出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1548
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资金
- NIGMS NIH HHS [R01 GM064750, R01 GM064750-07] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM064750] Funding Source: NIH RePORTER
ADAM ( a disintegrin and metalloprotease) proteins are membrane-anchored metalloproteases that process and shed the ectodomains of membrane-anchored growth factors, cytokines and receptors. ADAMs also have essential roles in fertilization, angiogenesis, neurogenesis, heart development and cancer. Research on ADAMs and their role in protein ectodomain shedding is emerging as a fertile ground for gathering new insights into the functional regulation of membrane proteins.
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