期刊
GENOME BIOLOGY
卷 6, 期 4, 页码 -出版社
BMC
DOI: 10.1186/gb-2005-6-4-r38
关键词
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资金
- NIGMS NIH HHS [P20 GM064361, P20 GM64361] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM064361] Funding Source: NIH RePORTER
We have generalized the derivation of genetic-interaction networks from quantitative phenotype data. Familiar and unfamiliar modes of genetic interaction were identified and defined. A network was derived from agar-invasion phenotypes of mutant yeast. Mutations showed specific modes of genetic interaction with specific biological processes. Mutations formed cliques of significant mutual information in their large-scale patterns of genetic interaction. These local and global interaction patterns reflect the effects of gene perturbations on biological processes and pathways.
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