期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 6, 期 1, 页码 21-31出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1550
关键词
-
类别
Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins, nesprins and SUN-domain proteins. These complexes have roles in chromatin organization, gene regulation and signal transduction. Some link the nucleoskeleton to cytoskeletal structures, ensuring that the nucleus and centrosome assume appropriate intracellular positions. These complexes provide new insights into cell architecture, as well as a foundation for the understanding of the molecular mechanisms that underlie the human laminopathies - clinical disorders that range from Emery - Dreifuss muscular dystrophy to the accelerated ageing seen in Hutchinson - Gilford progeria syndrome.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据