期刊
CURRENT MEDICINAL CHEMISTRY
卷 12, 期 2, 页码 237-246出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867053363397
关键词
caffeic acid derivative; salvianolic acid; antioxidant; anti-ischemia reperfusion; anti-thrombosis; anti-hypertension; anti-fibrosis; antivirus; antitumor; Salvia miltiorrhiza
Caffeic acid (3,4-dihydroxycinnamic acid), one of the most common phenolic acids, frequently occurs in fruits, grains and dietary supplements for human consumption as simple esters with quinic acid or saccharides, and are also found in traditional Chinese herbs. Caffeic acid derivatives occur as major water-soluble components of Salvia miltiorrhiza, including caffeic acid monomers and a wide variety of oligomers. This review provides up-to-date coverage of this class of phenolic acids in regard to structural classification, natural resources, chemical and biosyntheses, analytical methods and biological activities including antioxidant, anti-ischemia reperfusion, anti-thrombosis, anti-hypertension, anti-fibrosis, antivirus and antitumor properties. Special attention is paid to both structural classification and biological activities. The structural diversity and the pronounced biological activities encountered in the caffeic acid derivatives of S. miltiorrhiza indicate that this class of compounds is worthy of further studies that,may lead to new drug discovery.
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