期刊
AMERICAN JOURNAL OF HUMAN GENETICS
卷 76, 期 1, 页码 1-7出版社
CELL PRESS
DOI: 10.1086/426949
关键词
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资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH060343] Funding Source: NIH RePORTER
- NIMH NIH HHS [MH 60343] Funding Source: Medline
Admixture mapping extends to human populations the principles that underlie linkage analysis of an experimental cross. For detecting genes that contribute to ethnic variation in disease risk, admixture mapping has greater statistical power than family-linkage studies. In comparison with association studies, admixture mapping requires far fewer markers to search the genome and is less affected by allelic heterogeneity. Statistical-analysis programs for admixture mapping are now available, and a genomewide panel of markers for admixture mapping in populations formed by West African - European admixture has been assembled. Some of the remaining technical challenges include the ability to ensure that the statistical methods are robust and to develop marker panels for other admixed populations. Where admixed populations and panels of markers informative for ancestry are available, admixture mapping can be applied to localize genes that contribute to ethnic variation in any measurable trait.
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