期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 6, 期 1, 页码 44-55出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1546
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- NATIONAL CANCER INSTITUTE [ZIABC005795, Z01BC005795] Funding Source: NIH RePORTER
p53 mutants that lack DNA-binding activities, and therefore, transcriptional activities, are among the most common mutations in human cancer. Recently, a new role for p53 has come to light, as the tumour suppressor also functions in DNA repair and recombination. In cooperation with its function in transcription, the transcription-independent roles of p53 contribute to the control and efficiency of DNA repair and recombination.
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