期刊
CEREBRAL CORTEX
卷 15, 期 1, 页码 49-57出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhh107
关键词
D1 receptors; electrophysiology; NMDA; persistent activity; prefrontal cortex; puberty
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [R56MH057683, R01MH057683] Funding Source: NIH RePORTER
- NIMH NIH HHS [MH57683] Funding Source: Medline
Dopamine-glutamate interactions may contribute to persistent electrical activity in the prefrontal cortex (PFC). We tested whether a D-1 modulation of NMDA function can result in persistent depolarization in vitro. D-1-NMDA co-activation yielded depolarizing plateaus resembling in vivo up states in PFC pyramidal neurons recorded in slices from adult (PD 45-65), but not pre-pubertal (PD 29-38) rats. These plateaus required intracellular Ca2+, activation of L-type Ca2+ channels and protein kinase A. These events were eliminated by intracellular administration of the voltage-gated Na+ channel blocker QX-314 or by interrupting synaptic activity with bath application of tetrodotoxin or the AMPA antagonist CNQX, suggesting that they require both intrinsic and synaptic mechanisms. These recurrent depolarizations could constitute important elements in cortical information processing, allowing synaptic plasticity and memory functions. Acquiring these PFC D-1-NMDA interactions after puberty may be a critical element for developing mature cognitive abilities.
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