期刊
CURRENT MEDICINAL CHEMISTRY
卷 12, 期 6, 页码 657-666出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867053202214
关键词
betulinic acid; anti-HIV derivatives; anti-HIV mechanism; anticancer derivatives; anticancer mechanism; antiinflammatory; antimalarial; biotransformation
Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human immunodeficiency virus (HIV), antibacterial, antimalarial, anti inflammatory, anthelmintic and antioxidant properties. This article reports a survey of the literature dealing with betulinic acid related biological properties that has appeared from the 1990's to the beginning of 2003. A broad range of medical and pharmaceutical disciplines are covered, including a brief introduction about discovery, phytochemical aspects, organic synthesis, anti-HIV and cytotoxic mechanisms of action. Various structural modifications carried out and their biological and pharmacokinetic profiles are also incorporated.
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