期刊
NEW JOURNAL OF CHEMISTRY
卷 29, 期 9, 页码 1213-1218出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b508773b
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The self- assembly of two novel intramolecular hydrogen bonding- driven foldamers is described. Two linear symmetric aromatic amide oligomers, 1 and 2, which are incorporated with benzene subunits, have been prepared by continuous amide- coupling reactions. The existence of three- centred hydrogen bonds in the oligomers and consequently the folding conformation of the oligomers in solution have been characterized by H-1 NMR experiments and by comparing them with the reported solid state structure of the identical structural skeleton. Molecular modeling reveals a rigid crescent conformation for 1 with a cavity of ca. 0.9 nm in diameter and a helical conformation for 2 with a cavity of ca. 0.8 nm in diameter. Due to the existence of intramolecular hydrogen bonding, all the C = O groups in both oligomers are located inwardly. The binding of 1 and 2 towards a trihydroxyl guest and four saccharide derivatives have been investigated with H-1 NMR, fluorescence, and circular dichroism spectroscopy. The association constants of the corresponding 1 : 1 complexes have been determined by fluorescence titration experiments.
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