期刊
CHEMISTRY & BIODIVERSITY
卷 2, 期 10, 页码 1305-1309出版社
VERLAG HELVETICA CHIMICA ACTA AG
DOI: 10.1002/cbdv.200590101
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资金
- NATIONAL CANCER INSTITUTE [R01CA017625] Funding Source: NIH RePORTER
- NCI NIH HHS [CA17625] Funding Source: Medline
Monascin (1) constitutes one of the azaphilonoid pigments in the extracts of Monascus pilosus-fermented rice (red-mold rice). Compound 1 was evaluated for its anti-tumor-initiating activity via oral administration on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) or by ultraviolet light B (UVB) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Compound 1 exhibited marked inhibitory activity on both PN- and UVB-induced mouse skin carcinogenesis tests. These findings suggest that compound 1 may be valuable as potential cancer chemopreventive agent in chemical and environmental carcinogenesis.
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