期刊
PSYCHOSOMATIC MEDICINE
卷 67, 期 1, 页码 24-30出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.psy.0000151745.67285.c2
关键词
total cholesterol; cognition; cardiovascular risk factors
资金
- NHLBI NIH HHS [3R01 HL67358, 4R01 HL65177] Funding Source: Medline
- NIA NIH HHS [P30 AG13846, 5R01-AG 16495, 5R01-AG08122] Funding Source: Medline
- NINDS NIH HHS [5R01-NS17950] Funding Source: Medline
- PHS HHS [N01-25195] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL065177, R01HL067358] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS017950] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG008122, P30AG013846, R01AG016495] Funding Source: NIH RePORTER
Objective: The objective of this study was to examine the relationship between total cholesterol (TC) and cognitive performance within the context of the Framingham Heart Study, a large, community-based, prospective investigation of cardiovascular risk factors. Methods: Participants were 789 men and 1105 women from the Framingham Heart Study original cohort who were free of dementia and stroke and who received biennial TC determinations over a 16- to 18-year surveillance period. Cognitive tests were administered 4 to 6 years subsequent to the surveillance period and consisted of measures of learning, memory, attention/concentration, abstract reasoning, concept formation, and organizational abilities. Statistical models were adjusted for multiple demographic and biological covariates. Results: There was a significant positive linear association between TC and measures of verbal fluency, attention/concentration, abstract reasoning, and a composite score measuring multiple cognitive domains. Performance levels for three clinically defined groups were examined. Participants with desirable TC levels (<200 mg/dL) performed less well than participants with borderline-high TC levels (200-239 mg/dL) and participants with high TC levels (1240 mg/dL). Conclusions: Lower naturally occurring TC levels are associated with poorer performance on cognitive measures, which place high demands on abstract reasoning, attention/concentration, word fluency, and executive functioning.
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