期刊
CEREBROVASCULAR DISEASES
卷 20, 期 3, 页码 141-151出版社
KARGER
DOI: 10.1159/000087197
关键词
stroke; carotid artery stenosis; vascular dementia; intracranial haemorrhage; aneurysm; matrix metalloproteinases
Matrix metalloproteinases are important factors for tissue remodelling and are activated during several physiological and pathological conditions, including cerebrovascular diseases. We give an overview of the structure, production and physiological effects of these widely distributed proteases and describe the genetic background and regulation pathways. In particular, we discuss the role of matrix metalloproteinases in vascular remodelling concerning ischaemic stroke, brain haemorrhage, vascular dementia, carotid artery plaques and cerebral aneurysms. Copyright (C) 2005 S. Karger AG, Basel.
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