期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 19, 期 1, 页码 12-19出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2004.05.004
关键词
facial motoneuron; facial nerve injury; CD4(+) T cell; neurotrophic factors; immunodeficient mouse models
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS040433] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS-40433] Funding Source: Medline
In the field of neuroimmunology, an emerging area of research involves the role that the immune system plays in neural injury and repair. Such immune:neural interactions may involve both neuroprotective and neurodestruction actions. To begin to address the compelling, and clinically relevant, issue of how the immune system impacts neural reparative processes, we combined the well described facial nerve injury paradigm, a simple neural injury model, with various immunodeficient mouse models, in order to delineate the contributing immune cells/factors involved in neural injury and repair. We have discovered a role for the CD4(+) T cell in mediating facial motoneuron survival after facial nerve injury in the mouse. In this review, we present an overview of our work to date in this field and discuss future directions relevant to understanding key elements in the crosstalk between the immune:neural systems that develops subsequent to injury and/or trauma. (C) 2004 Elsevier Inc. All rights reserved.
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