期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 19, 期 1, 页码 121-130出版社
ELSEVIER
DOI: 10.1016/j.etap.2004.05.009
关键词
alkylphenol ethoxylates; bisphenol S; biodegradation products; chlorinated derivatives; estrogenic activity; GFP
Alkylphenol ethoxylates, widely used non-ionic surfactants, are biodegraded into alkylphenols such as nonylphenol (NP) and t-octylphenol (OP), short-chain ethoxylates such as NP-monoethoxylate (NP2EO) and NP-diethoxylate (NP2EO), and alkylphenoxy carboxylic acids such as 4-t-octylphenoxyacetic acid (OP1EC). Bisphenol S (BPS) is more heat-stable and photo-resistant than bisphenol A (BRA), and therefore replaces BPA. These chemicals could be chlorinated during wastewater treatment. We synthesized these compounds and their chlorinated derivatives to estimate their estrogenic activities using a GFP expression system. The EC50 of NT-related compounds was NP > CINP ranking > diCINP > NP2EO > CINP1EO > NP2EO. The estrogenic activity of OP1EC was 10 times less potent than parent OP. Furthermore. BPS showed comparable estrogenic activity with BPA. The EC50 ranking of BPS-related compounds was BPA > BPS > triCIBPS > diCIBPS > CIBPS. Other tested BPS derivatives had no estrogenic activity. Chlorination of the tested chemicals did not enhance their estrogenic activity. in contrast to certain chlorinated BPAs. Thus, our results demonstrated that chlorinated derivatives of NP, OP, and BPS, even if artificially produced during wastewater processing. were less estrogenic than their parent chemicals, known as endocrine disruptors. (C) 2004 Elsevier B.V. All rights reserved.
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