期刊
CARDIOLOGY IN REVIEW
卷 16, 期 6, 页码 273-279出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CRD.0b013e3181709fd8
关键词
toll-like receptors; atherosclerosis; immunity; immune modulators; inflammation cascade
The toll-like receptors (TLRs) are a class of transmembrane molecules that have important functions in both innate and acquired immunity. As part of the body's normal immune defense against microbial pathogens, stimulation of these receptors will trigger the inflammatory response cascade and the release of cytokines. Activation of these receptors also plays a role in a variety of systemic inflammatory diseases such as asthma, sepsis, atherosclerosis, acute corollary artery disease, and left ventricular remodeling. Pharmacologic approaches to modify the actions of TLRs are now under consideration as potential treatments for inflammatory systemic diseases that include atherosclerosis. At the same time, it is essential to characterize the benefits and risks of modifying such all important part of the body's innate immune system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据