期刊
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
卷 4, 期 11, 页码 887-896出版社
SPRINGERNATURE
DOI: 10.1039/b508756b
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资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL019242] Funding Source: NIH RePORTER
- Medical Research Council [MC_U117533887, MC_U117532185] Funding Source: Medline
- NHLBI NIH HHS [HL19242] Funding Source: Medline
- MRC [MC_U117532185, MC_U117533887] Funding Source: UKRI
A previous study of substituent effects on the photocleavage of 1-acyl-7-nitroindolines has been extended to examine the effects of electron-donating and electron-withdrawing substituents. 1-Acetyl-4,5-methylenedioxy-7-nitroindoline 7 was inert to 350 nm irradiation, reinforcing an earlier finding that excessive electron- donation by substituents can divert the excited state into non-productive pathways. By contrast, the 1-acetyl-5,7-dinitro- and 1-acetyl-4-methoxy-5,7-dinitroindolines 8 and 9 respectively both showed improved photolysis efficiency in aqueous solution compared to the 1-acyl-4-methoxy-7-nitro compound 2. Unlike 2, both 8 and 9 gave mixed photoproducts, the corresponding dinitroindolines and the 5-nitro-7-nitrosoindoles. These results are interpreted in terms of a previous mechanistic study. Investigation of the 4-methoxy-5,7-dinitroindoline conjugate of L-glutamate 18 showed that the stoichiometry of glutamate release upon photolysis was only 65-77% of the theoretical value, suggesting that photolysis of these dinitro compounds may involve pathways other than the clean photolysis previously observed for mono-nitro compounds such as 2.
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