期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 19, 期 5-6, 页码 357-360出版社
KARGER
DOI: 10.1159/000084705
关键词
butyrylcholinesterase; K genotype; Alzheimer's disease; dementia with Lewy bodies; phosphorylated tau; amyloid-beta; temporal cortex
Accumulating evidence suggests that butyrylcholinesterase (BuChE) plays an important role in the progression of cognitive deficits and Alzheimer-type pathology in dementia patients. We examined the relationship between the K variant of BuChE and the severity of deposits of amyloid (A beta(1-42)) and phosphorylated tau in the temporal cortex (BA36) of 30 prospectively studied autopsy-diagnosed dementia ( Alzheimer's disease and dementia with Lewy bodies) patients. There was 42% less phosphorylated tau in BA36 in cases with >= 1 K compared with those with wild-type BuChE alleles (t = 2.2, p = 0.039), but no difference in the extent of A beta(1-42) deposition. BuChE may play this role in the phosphorylation of tau, relevant to therapeutic inhibition of the enzyme. Copyright (C) 2005 S. Karger AG, Basel.
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