期刊
HISTOCHEMISTRY AND CELL BIOLOGY
卷 123, 期 1, 页码 1-18出版社
SPRINGER
DOI: 10.1007/s00418-004-0746-1
关键词
protozoan-ohost cell interaction; endocytosis; parasitophorous vacuole; electron microscopic cytochemistry
Some parasitic protozoa are able to penetrate into host cells where they multiply. The process of penetration involves steps such as attachment to the host cell surface, internalization of the protozoan through an endocytic process with the formation of a parasitophorous vacuole (PV), and the subsequent interaction of the protozoan with the membrane lining the PV. This review analyzes the biogenesis of the PV from a morphological and cytochemical perspective. Special emphasis is given to (a) the localization of plasma membrane-associated enzymes such as Na+-K+-ATPase, Ca2+-ATPase, 5'-nucleotidase, and NAD(P)H-oxidase, (b) glycoconjugates, detected using labeled lectins, (c) anionic sites, detected using cationic particles, and (d) integral membrane proteins, using freeze-fracture replicas, and lipids during the formation of the PV containing Trypanosoma cruzi, Leishmania, Toxoplasma gondii, and Plasmodium.
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