期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 26, 期 1, 页码 36-43出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2004.11.004
关键词
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资金
- NIMH NIH HHS [U01 MH69062] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [U01MH069062] Funding Source: NIH RePORTER
GABA, the main inhibitory neurotransmitter in the brain, regulates many physiological and psychological processes. Thus, dysfunction of the GABA system is implicated in the pathophysiology of several neuropsychiatric disorders, including anxiety and depression. However, the role of GABA(B) receptors in behavioural processes related to these disorders has not been resolved. GABAB receptors are G-protein-coupled receptors that function as heterodimers of GABA(B(1)) and GABA(B(2)) subunits. In addition to highly selective agonists and antagonists, novel GABAB receptor tools have been developed recently to further assist elucidation of the role of GABAB receptors in CNS function. These include mice that lack functional GABA(B) receptors, and novel positive modulators of the GABA(B) receptor. In this review, we discuss evidence that points to a role of GABA(B) receptors in anxiety and depression.
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