期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 5, 期 13, 页码 1221-1236出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802605774463042
关键词
MraY; translocase; antibacterial; antibiotic; tunicamycin; streptovirudin; corynetoxin; rbosamino-uridine; liposidomycin; FR-900493; caprazamycin; muraymycin; riburamycin; RU75411; uridylpeptide; mureidomycine; napsamycin; pacidamycin; capuramycin; A-500359A; lipopeptide; amphomycin; protein E
MraY presents all necessary biological requirements to be considered as a target of interest for the discovery of novel antibacterials. Furthermore, several inhibitors aimed at this enzyme have been discovered. Amphomycin, which is currently used as a topical antibacterial in the veterinary industry is one of them, but the major source of future developments resides in the nucleoside based inhibitors group. This group has been subdivided into classes: Tunicamycins, Ribosamino-uridines, Uridylpeptides and Capuramycins. Analysis of pharmacological behaviours observed with several compounds within these classes, shows that broad-spectrum antibacterial activii,y, including relevant resistant strains and in vivo efficacy without toxicity are achievable. Among them, Caprazamycins, Aluraymycins, Riburamycins and Capuramycins present the most promising profiles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据