期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 59, 期 1, 页码 189-196出版社
ELSEVIER
DOI: 10.1016/j.ejpb.2004.06.008
关键词
hot-melt extrusion; lidocaine texture analyzer; muco-adhesive films; hydroxypropyl cellulose; hydroxypropyl methyl cellulose
Hot-melt extrusion technology was used to produce thin films containing a model drug, lidocaine, and the cellulosic polymers hydroxypropyl cellulose (HPC) and hydroxypropyl methyl cellulose (HPMC). Two film formulations were extruded and compared, one containing only HPC and the other containing HPC:HPMC (80:20). Thermal analysis of the films using differential scanning calorfinetry (DSC) suggested that the drug existed in the amorphous condition, which was confirmed by wide angle X-ray diffiractometry. Sustained release of the drug was observed from both of the polymer matrices. Dissolution profiles suggested that HPMC retarded the drug release front HPC:HPMC (80:20) films. However, the mechanism of drub release from both of the films was predominantly diffusion of the drug through the polymer matrices. Incorporation of HPMC also increased both adhesive strength and work of adhesion as compared to the HPC -only films. (C) 2004 Elsevier B.V. All rights reserved.
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