相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer
James G. Jackson et al.
CANCER CELL (2012)
Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration
W. Andrew Yeudall et al.
CARCINOGENESIS (2012)
Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence
Tongyuan Li et al.
CELL (2012)
Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
William A. Freed-Pastor et al.
CELL (2012)
TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence
Heath D. Skinner et al.
CLINICAL CANCER RESEARCH (2012)
Prognostic significance of Bcl-2 in invasive mammary carcinomas: a comparative clinicopathologic study between triple-negative and non-triple-negative tumors
Kareem Tawfik et al.
HUMAN PATHOLOGY (2012)
Links between mutant p53 and genomic instability
Walter Hanel et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2012)
Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models
Cynthia X. Ma et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
Sohrab P. Shah et al.
NATURE (2012)
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
Marco Gerlinger et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport
Fan Zhang et al.
BIOCHEMICAL PHARMACOLOGY (2011)
Limited importance of the dominant-negative effect of TP53 missense mutations
Ewelina Stoczynska-Fidelus et al.
BMC CANCER (2011)
Estrogen levels act as a rheostat on p53 levels and modulate p53-dependent responses in breast cancer cell lines
Lynnette Fernandez-Cuesta et al.
BREAST CANCER RESEARCH AND TREATMENT (2011)
A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer
Javier E. Girardini et al.
CANCER CELL (2011)
Multiple Stress Signals Activate Mutant p53 In Vivo
Young-Ah Suh et al.
CANCER RESEARCH (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop
Fabio Valenti et al.
CELL CYCLE (2011)
Mutant p53R175H upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells
I. Kogan-Sakin et al.
CELL DEATH AND DIFFERENTIATION (2011)
p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
G. Melino
CELL DEATH AND DIFFERENTIATION (2011)
SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis
D. Li et al.
CELL DEATH AND DIFFERENTIATION (2011)
HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab
Shanu Modi et al.
CLINICAL CANCER RESEARCH (2011)
Minireview: IGF, Insulin, and Cancer
Emily J. Gallagher et al.
ENDOCRINOLOGY (2011)
Mutant p53 Disrupts MCF-10A Cell Polarity in Three-dimensional Culture via Epithelial-to-mesenchymal Transitions
Yanhong Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The Multifaceted Roles of Autophagy in Tumors-Implications for Breast Cancer
Jayanta Debnath
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2011)
The molecular pathology of breast cancer progression
Alessandro Bombonati et al.
JOURNAL OF PATHOLOGY (2011)
Mutant p53 gain of function is interwoven into the hallmarks of cancer
Hilla Solomon et al.
JOURNAL OF PATHOLOGY (2011)
TopBP1 Mediates Mutant p53 Gain of Function through NF-Y and p63/p73
Kang Liu et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Dominant-Negative Features of Mutant TP53 in Germline Carriers Have Limited Impact on Cancer Outcomes
Paola Monti et al.
MOLECULAR CANCER RESEARCH (2011)
Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells
Dun Li et al.
MOLECULAR CANCER RESEARCH (2011)
TP53 status for prediction of sensitivity to taxane versus non-taxane neoadjuvant chemotherapy in breast cancer (EORTC 10994/BIG 1-00): a randomised phase 3 trial
Herve Bonnefoi et al.
LANCET ONCOLOGY (2011)
Tumour evolution inferred by single-cell sequencing
Nicholas Navin et al.
NATURE (2011)
Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
Jie Xu et al.
NATURE CHEMICAL BIOLOGY (2011)
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
Simon A. Forbes et al.
NUCLEIC ACIDS RESEARCH (2011)
ChIP-on-Chip Analysis of In Vivo Mutant p53 Binding To Selected Gene Promoters
Stefania Dell'Orso et al.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2011)
p53 mutant breast cancer patients expressing p53 gamma have as good a prognosis as wild-type p53 breast cancer patients
Jean-Christophe Bourdon et al.
BREAST CANCER RESEARCH (2011)
Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation
Tiziana Bruno et al.
CANCER CELL (2010)
Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53
Perry Stambolsky et al.
CANCER CELL (2010)
Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors
Shinya Ohashi et al.
CANCER RESEARCH (2010)
Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content
Salvatore Pece et al.
CELL (2010)
p73 tumor suppressor protein A close relative of p53 not only in structure but also in anti-cancer approach?
Joanna Zawacka-Pankau et al.
CELL CYCLE (2010)
p53-family proteins and their regulators: hubs and spokes in tumor suppression
L. Collavin et al.
CELL DEATH AND DIFFERENTIATION (2010)
Detailed Haplotype Analysis at the TP53 Locus in p.R337H Mutation Carriers in the Population of Southern Brazil: Evidence for a Founder Effect
Sonia Garritano et al.
HUMAN MUTATION (2010)
Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells
Laureline Roger et al.
JOURNAL OF CELL SCIENCE (2010)
Restoration of DNA-Binding and Growth-Suppressive Activity of Mutant Forms of p53 Via a PCAF-Mediated Acetylation Pathway
Ricardo E. Perez et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2010)
Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells
Rachel Sarig et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Altered-Function p53 Missense Mutations Identified in Breast Cancers Can Have Subtle Effects on Transactivation
Jennifer J. Jordan et al.
MOLECULAR CANCER RESEARCH (2010)
Pharmacological reactivation of mutant p53: from protein structure to the cancer patient
K. G. Wiman
ONCOGENE (2010)
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
Jennifer P. Morton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation
Santhi D. Konduri et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences
Daniel Menendez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures
Hideaki Mizuno et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
p53 post-translational modification: deregulated in tumorigenesis
Chao Dai et al.
TRENDS IN MOLECULAR MEDICINE (2010)
TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use
Magali Olivier et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
p63 and p73, the Ancestors of p53
V. Doetsch et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Mutant p53 mediates survival of breast cancer cells
L. Y. Lim et al.
BRITISH JOURNAL OF CANCER (2009)
High Frequency of TP53 Mutation in BRCA1 and Sporadic Basal-like Carcinomas but not in BRCA1 Luminal Breast Tumors
Elodie Manie et al.
CANCER RESEARCH (2009)
The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells
Angelo Cicalese et al.
CELL (2009)
Mutant p53 Drives Invasion by Promoting Integrin Recycling
Patricia A. J. Muller et al.
CELL (2009)
A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis
Maddalena Adorno et al.
CELL (2009)
Identification of GRO1 as a Critical Determinant for Mutant p53 Gain of Function
Wensheng Yan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The basics of epithelial-mesenchymal transition
Raghu Kalluri et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Regulation of p53 by TopBP1: a Potential Mechanism for p53 Inactivation in Cancer
Kang Liu et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Modulation of microRNA processing by p53
Hiroshi I. Suzuki et al.
NATURE (2009)
The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis
Giulia Fontemaggi et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions
D. Walerych et al.
ONCOGENE (2009)
Association of the germline TP53 R337H mutation with breast cancer in southern Brazil
Juliana G. Assumpcao et al.
BMC CANCER (2008)
The molecular journey from ductal carcinoma in situ to invasive breast cancer
Lisa Wiechmann et al.
CANCER (2008)
Peptide aptamers targeting mutant p53 induce apoptosis in tumor cells
Elisa Guida et al.
CANCER RESEARCH (2008)
The epithelial-mesenchymal transition generates cells with properties of stem cells
Sendurai A. Mani et al.
CELL (2008)
The disruption of the protein complex mutantp53/p73 increases selectively the response of tumor cells to anticancer drugs
Silvia Di Agostino et al.
CELL CYCLE (2008)
Mutant p53 protein localized in the cytoplasm inhibits autophagy
Eugenia Morselli et al.
CELL CYCLE (2008)
A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis
L. Weinmann et al.
CELL DEATH AND DIFFERENTIATION (2008)
The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss
Tamara Terzian et al.
GENES & DEVELOPMENT (2008)
Chaperone-dependent stabilization and degradation of p53 mutants
P. Muller et al.
ONCOGENE (2008)
Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway
J. E. Kravchenko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
Frank M. Boeckler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells
Damian J. Junk et al.
NEOPLASIA (2008)
Mutant p53 R270H gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis
Christina Heinlein et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
Ubiquitination and degradation of mutant p53
Natalia Lukashchuk et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
Fiamma Mantovani et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Estrogen receptor α inhibits p53-mediated transcriptional repression:: Implications for the regulation of apoptosis
Aejaz Sayeed et al.
CANCER RESEARCH (2007)
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype:: Lessons from recent developments in the IARC TP53 database
Audrey Petitjean et al.
HUMAN MUTATION (2007)
Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage
Susan W. P. Wijnhoven et al.
CANCER RESEARCH (2007)
P53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
Hoseok Song et al.
NATURE CELL BIOLOGY (2007)
Cytoplasmic mutant p53 increases Bcl-2 expression in estrogen receptor-positive breast cancer cells
M. A. Christine Pratt et al.
APOPTOSIS (2007)
Mutant p53 enhances nuclear factor κB activation by tumor necrosis factor α in cancer cells
Lilach Weisz et al.
CANCER RESEARCH (2007)
Aberrant expression of TopBP1 in breast cancer
J. J. Going et al.
HISTOPATHOLOGY (2007)
Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen
Philippe Bertheau et al.
PLOS MEDICINE (2007)
Coping with stress: multiple ways to activate p53
H. F. Horn et al.
ONCOGENE (2007)
Association of p53 gene alterations with the expression of antiapoptotic survivin splice variants in breast cancer
F. Vegran et al.
ONCOGENE (2007)
p16INK4a modulates p53 in primary human mammary epithelial cells
Jianmin Zhang et al.
CANCER RESEARCH (2006)
Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
Silvia Di Agostino et al.
CANCER CELL (2006)
Posttranslational phosphorylation of mutant p53 protein in tumor development
Manabu Matsumoto et al.
MEDICAL MOLECULAR MORPHOLOGY (2006)
Estrogen receptor-α binds p53 tumor suppressor protein directly and represses its function
WS Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer
M Olivier et al.
CLINICAL CANCER RESEARCH (2006)
Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress
D Speidel et al.
ONCOGENE (2006)
Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development
SWP Wijnhoven et al.
CANCER RESEARCH (2005)
p53 isoforms can regulate p53 transcriptional activity
JC Bourdon et al.
GENES & DEVELOPMENT (2005)
Epigenetic mechanisms affect mutant p53 transgene expression in WAP-mutp53 transgenic mice
F Krepulat et al.
ONCOGENE (2005)
PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosis
VJN Bykov et al.
ONCOGENE (2005)
MDM2 is a central node in the p53 pathway: 12 years and counting
GL Bond et al.
CURRENT CANCER DRUG TARGETS (2005)
How many mutant p53 molecules are needed to inactivate a tetramer?
WM Chan et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
GA Lang et al.
CELL (2004)
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
KP Olive et al.
CELL (2004)
Ser392 phosphorylation regulates the oncogenic function of mutant p53
DBS Yap et al.
CANCER RESEARCH (2004)
Chromosomal comparative genomic hybridization abnormalities in early- and late-onset human breast cancers: correlation with disease progression and TP53 mutations
YJ Jong et al.
CANCER GENETICS AND CYTOGENETICS (2004)
被撤回的出版物: Transactivation of the EGR1 gene contributes to mutant p53 gain of function (Retracted article. See vol. 79, pg. 2085, 2019)
L Weisz et al.
CANCER RESEARCH (2004)
Mutational spectrum of p53 mutations in primary breast and ovarian tumors
A Feki et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2004)
The combination of p53 mutation and neu/erbB-2 amplification is associated with poor survival in node-negative breast cancer
SB Bull et al.
JOURNAL OF CLINICAL ONCOLOGY (2004)
Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes
MJ Scian et al.
ONCOGENE (2004)
Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer
H Yamashita et al.
BREAST CANCER RESEARCH (2004)
Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
S Kato et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
A mutant TP53 gene status is associated with a poor prognosis and anthracycline-resistance in breast cancer patients
E Rahko et al.
EUROPEAN JOURNAL OF CANCER (2003)
Physical interaction with human tumor-derived p53 mutants inhibits p63 activities
S Strano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A peptide that binds and stabilizes p53 core domain:: Chaperone strategy for rescue of oncogenic mutants
A Friedler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
VJN Bykov et al.
NATURE MEDICINE (2002)
p53 as a mutagen test in breast cancer
KA Hill et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2002)
TP53 mutation patterns in breast cancers: searching for clues of environmental carcinogenesis
M Olivier et al.
SEMINARS IN CANCER BIOLOGY (2001)
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
T Sorlie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival
AN Jain et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Distinct pattern of p53 phosphorylation in human tumors
T Minamoto et al.
ONCOGENE (2001)
A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain
C Gaiddon et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Mutant p53 forms a complex with Sp1 on HIV-LTR DNA
A Chicas et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model
KL Murphy et al.
FASEB JOURNAL (2000)
Physical and functional interaction between p53 mutants and different isoforms of p73
S Strano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Molecular portraits of human breast tumours
CM Perou et al.
NATURE (2000)
High metastatic potential in mice inheriting a targeted p53 missense mutation
G Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy
AN Bullock et al.
ONCOGENE (2000)
分享论文
