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注意:仅列出部分参考文献,下载原文获取全部文献信息。Molecular Cooperation between the Werner Syndrome Protein and Replication Protein A in Relation to Replication Fork Blockage
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ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery
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WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations
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Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis
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The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest
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Werner syndrome helicase activity is essential in maintaining fragile site stability
Livia Maria Pirzio et al.
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Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway
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JOURNAL OF CELL BIOLOGY (2008)
Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint
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MOLECULAR BIOLOGY OF THE CELL (2008)
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Replication fork regression in vitro by the Werner syndrome protein (WRN): Holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity
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The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
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Linkage between Werner syndrome protein and the Mre11 complex via Nbs1
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The Werner syndrome protein has separable recombination and survival functions
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DNA REPAIR (2004)
WRN interacts physically and functionally with the recombination mediator protein RAD52
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Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein
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RecQ helicases: multiple roles in genome maintenance
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WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair
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Alternate pathways involving Sgs1/Top3, Mus81/Mus81, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication
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The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro
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Homologous recombination resolution defect in Werner syndrome
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MOLECULAR AND CELLULAR BIOLOGY (2002)
Asymmetry of DNA replication fork progression in Werner's syndrome
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Coordinate action of the helicase and 3′ to 5′ exonuclease of Werner syndrome protein
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease
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Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle
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MOLECULAR BIOLOGY OF THE CELL (2001)
Interactions between the Werner syndrome helicase and DNA polymerase δ specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51
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Werner syndrome cells are sensitive to DNA crosslinking drugs
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Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1
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MOLECULAR AND CELLULAR BIOLOGY (2000)
Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage
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MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2000)
Lessons from human progeroid syndromes
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Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest
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Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA
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