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Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy

期刊

JOURNAL OF VIRAL HEPATITIS
卷 12, 期 5, 页码 456-464

出版社

WILEY
DOI: 10.1111/j.1365-2893.2005.00624.x

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disease progression; genotypes; hepatitis B virus; mutants; therapy

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Phylogenetic analysis has led to the classification of hepatitis B virus into eight genotypes, designated A to H. The genotypes have differences in biological properties and show heterogeneity in their global distribution. These attributes of the genotypes may account not only for differences in the prevalence of hepatitis B virus mutants in various geographic regions, but also be responsible for differences in the clinical outcome and response to antiviral treatment in different population groups.

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