期刊
JOURNAL OF PINEAL RESEARCH
卷 39, 期 2, 页码 99-104出版社
WILEY
DOI: 10.1111/j.1600-079X.2005.00248.x
关键词
antioxidant enzymes; calmodulin; melatonin; NF-kappa B pathway; oxidative stress; ROR alpha
Melatonin, the main secretory product of the pineal gland, is known to collaborate against oxidative stress within cells, but its mechanism of action in terms of stimulating antioxidant enzymes remains unclear. Herein, we propose that melatonin modulates antioxidant enzyme activities via its interaction with calmodulin, which in turn inhibits downstream processes that lead to the inactivation of nuclear ROR alpha melatonin receptor. Eventually, this nuclear transcription factor downregulates NF-kappa B-induced antioxidant enzyme expression. Therefore, the increment in antioxidant enzyme activities induced by melatonin involves the inhibition of the ROR alpha pathway. Thus, in addition to its direct free radical scavenging activities, melatonin has important actions in oxidative defense by stimulating enzymes which metabolize free radicals and radical products to innocuous metabolites.
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