期刊
MULTISCALE MODELING & SIMULATION
卷 3, 期 2, 页码 440-475出版社
SIAM PUBLICATIONS
DOI: 10.1137/040603760
关键词
blood flow heterogeneity; growth laws; physiologically structured lattice model; cell-cycle; p27; p53; multiple scales
We present a physiologically structured lattice model for vascular tumor growth which accounts for blood flow and structural adaptation of the vasculature, transport of oxygen, interaction between cancerous and normal tissue, cell division, apoptosis, vascular endothelial growth factor release, and the coupling between these processes. Simulations of the model are used to investigate the effects of nutrient heterogeneity, growth and invasion of cancerous tissue, and emergent growth laws.
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