期刊
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
卷 60, 期 4, 页码 224-231出版社
KARGER
DOI: 10.1159/000089100
关键词
endometriomas; ultrasound-guided drainage; GnRH analogues; immunology; recombinant interleukin-2; treatment
Background: To analyze the therapeutic results of one dose of 3 million IU of recombinant interleukin-2 (rIL-2) left intracyst ( group I) versus two doses with a 1-month interval ( group II) after transvaginal ultrasound ( US)guided drainage of endometriomas under the effect of GnRH analogues. Methods: Prospective and randomized clinical trial ( helped by a random number table) at a University Hospital. Twenty-four consecutive patients with endometriomas initially sent to us for laparotomy and conservative surgery for endometriosis were included. Interventions: Treatment with GnRH analogues every 28 days, 3 doses. Under their effect, one or two transvaginal US-guided punctures were performed in order to aspirate the endometriomas, and 3 million IU of rIL-2 were left in the aspirated cysts each time. Main outcome measures: Clinical results: two menstruations after GnRH analogues. Other secondary outcome measures were: the time until recurrence of cysts, symptoms and CA-125 > 35 U/ml, and the need for further medical or surgical treatment. Results: They were moderate or good in >50% of cases with one drainage and one dose of 3 million IU of rIL-2 intracyst, but were better with a second drainage and two doses of rIL-2 ( 25 vs. 58.3% 'good results'). There were fewer recurrences and the interval before recurrence was longer after two doses but differences were not significant. Six patients from group I (50%) and 3 from group II (25%) needed laparotomy and conservative surgery at 17.5 +/- 8.7 months ( total time of follow-up = 33 +/- 8.8 months). Conclusions: Treatment of endometriomas with transvaginal US-guided drainage and rIL-2 left in the cysts under endometrial suppressive therapy with GnRH analogues has beneficial effects, improving clinical manifestations and avoiding some surgical therapies. The use of a higher dose of rIL-2 does not produce better results, whereas drainage +rIL-2 twice does. Copyright (C) 2005 S. Karger AG, Basel.
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