期刊
DIGESTION
卷 72, 期 4, 页码 248-253出版社
KARGER
DOI: 10.1159/000089960
关键词
Crohn's disease; Crohn's disease, surgery; perforating disease; smoking
Background/Aims: The majority of Crohn's disease patients undergo surgery. However, the factors that predict post-operative recurrence remain controversial. The aim of the present study was to shed light on the potential predictors of such recurrence. Methods: 86 patients who underwent operative procedures for Crohn's disease were retrospectively studied. Recurrence was defined as the need for a second operation. Life table and multivariate analysis were performed to find the predictors of recurrence. Results: In 26/86 (30%) of the patients, postoperative recurrence was diagnosed within a mean of 42 months of the follow-up. Logistic regression analysis revealed that smoking ( OR 3.69, 95% CI 2.06-11.52) and perforating disease ( OR 4.09, 95% CI 1.31-12.65) were associated with a risk of recurrence. However, survival analysis showed that only perforating disease was associated with an early post-operative recurrence (log-rank test, p < 0.001). Neither resected surgical specimen characteristics, nor the duration and the location of the disease were found to predict the need for a second operation. Conclusion: The risk for Crohn's disease patients who undergo surgery is related to the presence of perforating disease and smoking, which predict the need for a second operation. The former is associated with an even earlier recurrence. Copyright (c) 2005 S. Karger AG, Basel.
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