期刊
JOURNAL OF BONE AND MINERAL METABOLISM
卷 23, 期 -, 页码 11-15出版社
SPRINGER JAPAN KK
DOI: 10.1007/BF03026317
关键词
osteoclasts; osteoblasts; apoptosis; regulation
资金
- NIAMS NIH HHS [AR43510, AR48697] Funding Source: Medline
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR048697, R01AR043510] Funding Source: NIH RePORTER
NF-kappa B and c-Fos are transcription factors that are activated in immune cells and in most other cell types following stimulation by a variety of factors, including cytokines. growth factors. and hormones. They regulate the expression of a large number of genes, and both are activated in osteoclast precursors after RANKL, IL-1, or TNF bind to their respective receptors. However, of these cytokines. only RANKL is required for the induction of osteoclast formation in vivo. Nevertheless, it is likely that IL-1, TNF, and other cytokines participate in the upregulation of osteoclast formation seen in a variety of conditions that affect the skeleton in which cytokine production is increased, including estrogen deficiency and inflammatory bone diseases. In this review, the RANKL/ OPG/RANK system and roles for NF-kappa B and c-Fos in osteoclasts are reviewed along with our current understanding of how this system may be disrupted in common bone diseases, Such as postmenopausal osteoporosis, inflammatory arthritis. and Paget's disease.
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