期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 29, 期 4-5, 页码 707-714出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2005.03.013
关键词
depression; drug withdrawal; Pavlovian conditioning; conditioned place preference; nicotine; object recognition; reward learning
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [R03MH057240] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA011893] Funding Source: NIH RePORTER
- NIDA NIH HHS [DA06092, DA11893] Funding Source: Medline
- NIMH NIH HHS [MH57240] Funding Source: Medline
A decrease in sensitivity to pleasurable stimuli, anhedonia, is a major symptom of depression in humans. Several animal models have been developed to simulate this symptom (e.g. drug withdrawal, learned helplessness) using reward-sensitive procedures such as intracranial selfstimulation and progressive ratio responding as a measure of reward function. Recently, we introduced the use of another procedure, novelobject place conditioning in rats, to measure reward function in an associative learning situation. Withdrawal from chronic nicotine blocked a place preference conditioned by access to novel objects. This blockade was not due to impairment of object interaction, general activity, novelty detection, environmental familiarization, or expression of learning. Consequently, nicotine withdrawal directly reduced the rewarding properties of novelty. It is proposed that the novel-object place conditioning procedure could be usefully extended to other experimental situations and to genetically altered mice, so as to better understand the processes underlying changes in reward function. (c) 2005 Elsevier Ltd. All rights reserved.
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