期刊
JOURNAL OF BIOMEDICAL SCIENCE
卷 12, 期 1, 页码 13-29出版社
BMC
DOI: 10.1007/s11373-004-8169-5
关键词
CD7; CD43; CD45; galectin-1; integrin; laminin
Galectins are a family of animal lectins defined by two properties: shared amino acid sequences in their carbohvdrate-recognizing domain, and beta-galactoside affinity. A wide variety of biological phenomena are related to galectins, i.e., development, differentiation, morphogenesis, tumor metastasis, apoptosis, RNA splicing, and immunoregulatory function. In this review, we will focus on galectin-1 receptors, and some of the mechanisms by which this lectin affects different cell types. Several galectin-1 receptors are discussed such as CD45, CD7, CD43, CD2, CD3, CD4, CD107, CEA, actin, extracellular matrix proteins such as laminin and fibronectin, glycosaminoglycans, integrins, a beta-lactosamine glycolipid, GM1 ganglioside, polypeptide HBGp82, glycoprotein 90 K/MAC-2BP, CA125 cancer antigen, and pre-B cell receptor.
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