期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 29, 期 3, 页码 185-203出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2004.07.003
关键词
IMGT; immunoglobulin; T cell receptor; constant domain; immunoglobulin superfamily; V-set; C-set; Colliers de Perles
IMGT, the international ImMunoGeneTics information system(R) (http://imgt.cines.fr) provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), and related proteins of the immune system (RPI) of human and other vertebrates. The NUMEROTATION concept of IMGT-ONTOLOGY has allowed to define a unique numbering for the variable domains (V-DOMAINs) and for the V-LIKE-DOMAINs. In this paper, this standardized characterization is extended to the constant domains (C-DOMAINs), and to the C-LIKE-DOMAINs, leading. for the first time, to their standardized description of mutations, allelic polymorphisins, two-dimensional (2D) representations and tridimensional (3D) structures. The IMGT unique numbering is, therefore, highly valuable for the comparative, structural or evolutionary studies of the immunoglobulin superfamily (IgSF) domains. V-DOMAINs and C-DOMAINs of IG and TR in vertebrates, and V-LIKE-DOMAINs and C-LIKE-DOMAINs of proteins other than IG and TR, in any species. (C) 2004 Elsevier Ltd. All rights reserved.
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