期刊
CARBON
卷 71, 期 -, 页码 166-175出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.carbon.2014.01.025
关键词
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资金
- National Natural Science Foundation of China (NSFC) [20874043]
- National Basic Research Program of China [2011CB933400]
- Science and Technology Support Program (Society Development) of Jiangsu Province [BE2012735]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- National Science Foundation of China [31200817, 81220108008, 31171016]
- Jiangsu Province's Key Medical Center
Using a random polymerization process on graphene oxide (GO), graphene oxide grafted with oligomers containing phosphorylcholine moieties (GO-PCn) was synthesized. The synthesis products were characterized by atomic force microscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis and X-ray diffraction. The results revealed that the synthesized GO-PCn possessed greatly improved water solubility and remained stable in cell culture medium for several months. To evaluate the cytotoxicity of the GO-PCn, three cell lines (human umbilical vein endothelial cells, 264.7 murine macrophages and L929 murine fibroblasts) were cultured in different concentrations of GO and GO-PCn. GO-PCn demonstrated improved biocompatibility with all three cell lines. To investigate the mechanism of cellular uptake of the GO-PCn, fluorescein isothiocyanate-labeled GO-PCn was prepared. The results indicated that GO-PCn was incorporated by each cell type through endocytosis a consequence of its near-micrometer size and that it had no significant cytotoxicity. (C) 2014 Elsevier Ltd. All rights reserved.
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