期刊
MOLECULAR PHARMACEUTICS
卷 2, 期 1, 页码 22-28出版社
AMER CHEMICAL SOC
DOI: 10.1021/mp049907k
关键词
cationic lipid; plasmid DNA; costimulatory molecules; TNF-alpha; lymph nodes
资金
- NIH [CA74918, AI48851]
- NATIONAL CANCER INSTITUTE [R01CA074918] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI048851, R01AI048851] Funding Source: NIH RePORTER
A novel and improved vaccine delivery system and/or adjuvant is actively sought to enhance the potency of vaccines. Previously, we reported that strong antitumor immunity could be generated when a peptide antigen was incorporated into LPD (cationic liposome-polycation-pDNA) nanoparticles. In this study, we found that both the cationic liposome and DNA are required for the full immunostimulation activity of LPD. The unique ability of LPD to readily move into local lymphoid tissues and to activate antigen-presenting cells might be responsible for its strong immunostimulatory activity. Moreover, cationic liposome stimulates the expression of CD80/CD86 on dendritic cells (DCs), but not the release of TNF-alpha from DCs, suggesting the existence of a NF-kappa B-independent immunostimulation pathway for cationic lipids such as DOTAP.
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