期刊
CARBON
卷 50, 期 8, 页码 3001-3007出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.carbon.2012.02.083
关键词
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资金
- National Natural Science Foundation of China [21074152, 20874116]
- Education Ministry in China [20090171110023]
- Key Project of Scientific and Technical Innovation for Universities in Guangdong Province, China [cxzd1102]
Graphene oxide nanosheets were used to induce the in situ gelation of doxorubicin hydrochloride as an antitumor drug. When a very small amount of the graphene oxide was introduced into an aqueous solution of doxorubicin hydrochloride at room temperature, a strong and thixotropic gel was rapidly formed without any polymers or chemical additives. The gelation mechanism was investigated by fluorescence spectroscopy, X-ray diffraction and scanning electron microscopy. The encapsulated doxorubicin hydrochloride was found to show sustained release and antitumor efficacy. (C) 2012 Elsevier Ltd. All rights reserved.
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