A chemiluminescence sensor for determination of epinephrine using graphene oxide-magnetite-molecularly imprinted polymers

A chemiluminescence (CL) sensor for the determination of epinephrine using the system of luminol-NaOH-H2O2 based on a graphene oxide-magnetite-molecularly imprinted polymer (GM-MIP) is described. The epinephrine GM-MIP was synthesized using graphene oxide (G) which improved the adsorption capacity, and magnetite nanoparticles which made the polymers easier to use in the sensor. The adsorption performance and properties were characterized. The GM-MIP was used in CL analysis to increase the selectivity and the possible mechanism was also discussed. The CL sensor responded linearly to the concentration of epinephrine over the range 1.04 x 10(-7)-7.06 x 10(-3) mol/L with a detection limit of 1.09 x 10(-9) mol/L (3 sigma). The relative standard deviation for determination was 3.87%. On the basis of speediness and sensitivity, the sensor is reusable and shows a great improvement in selectivity and adsorption capacity over other sensors. The sensor had been used for the determination of epinephrine in drug samples. (C) 2012 Elsevier Ltd. All rights reserved.