期刊
CARBON
卷 50, 期 6, 页码 2162-2170出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.carbon.2012.01.026
关键词
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资金
- Program for New Century Excellent Talents in University [NCET-08-0897]
- National 973 Project [2010CB933901]
- Shanghai Sci. & Tech. and Education Committee [09SG43, S30406]
- Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University [DZL806]
Novel magnetic resonance imaging (MRI) contrast agents composed of multiwalled carbon nanotubes decorated with magnetic iron oxide nanoparticles were explored. They were functionalized with multilayer polyelectrolytes through layer-by-layer assembling and were shown to be hydrophilic, biocompatible, and have a high MRI contrast. A targeted ligand folic acid was chemically bonded to the functionalized nanotubes for specific targeting and imaging of cancer cells in MRI. The results demonstrate that the material can be used as ideal targeted imaging agents and is sufficient to obtain strong MRI contrast. (C) 2012 Elsevier Ltd. All rights reserved.
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