期刊
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
卷 15, 期 4, 页码 559-574出版社
TAYLOR & FRANCIS INC
DOI: 10.1081/BIP-200062852
关键词
adaptive methods; ancillary statistic; blinding; continuous outcome; clinical trials; conditioning; correlation; dichotomous outcome; independence; internal pilot study; lumping; pooling; power; restricted design; unrestricted design
Sample size calculations are important and difficult in clinical trails because they depend on the nuisance parameter and treatment effect. Recently, much attention has been focused on two-stage methods whereby the first stage constitutes an internal pilot study used to estimate parameters and revise the final sample size. This paper reviews two-stage methods based on estimation of nuisance parameters in either a continuous or dichotomous outcome setting.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据