期刊
EUROPEAN JOURNAL OF MASS SPECTROMETRY
卷 11, 期 3, 页码 325-333出版社
SAGE PUBLICATIONS LTD
DOI: 10.1255/ejms.745
关键词
electrospray; MS/MS; benzylisoquinoline alkaloids; atmospheric pressure photoionization; mass spectral fragmentation
Benzylisoquinoline alkaloids found in the Papaveraceae family play a major role in pharmaceutical biology. This is the first systematic study dealing with electrospray tandem mass spectrometry (ESI-MS/MS) of all benzylisoquinolines found as biogenetic precursors of morphinan alkaloids. Tandem mass spectral data are presented for norlaudanosoline, laudanosoline, 4'-O-methyl-norlaudanosoline, 6-O-methyl-norlaudanosoline, norcoclaurine, coclaurine, N-methylcoclaurine, N-methyl-3'-hydroxycoclaurine, N-methyl-3'-O-methylcoclaurine, norreticuline and reticuline. This study compares results obtained using an ion trap mass spectrometer with those obtained using a triple quadrupole one. The results highlight the differences between the tandem-in-time versus the tandem-in-space principle, often hampering the development of ESI-MS/MS libraries. In addition, the use of the atmospheric pressure photoionisation technique for the analysis of such substances is discussed.
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