期刊
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
卷 27, 期 1, 页码 31-37出版社
PROUS SCIENCE, SAU-THOMSON REUTERS
DOI: 10.1358/mf.2005.27.1.875434
关键词
dopamine D-1/D-2 receptor; jaw movements; magnet-sensing system; NMDA receptor; substantia nigra pars reticulata; ventrolateral striatum
The effects of NMDA and MK-801 injected into the substantia nigra pars reticulata on jaw movements evoked by dopamine D-1/D-2 receptor stimulation in the ventrolateral striatum were examined in freely moving rats, by using a magnet-sensing system combined with intracerebral drug microinjection technique. Bilateral injections of a mixture of SKF 82958 (5 mu g) and quinpirole (10 mu g), agonist at dopamine D, and D-2 receptors respectively, into the ventrolateral striatum elicited repetitive jaw movements. Bilateral injections of NMDA (0.01 and 0.05 mu g/0.2 mu l in each side) into the substantia nigra pars reticulata, which alone did not produce jaw movements, reduced the repetitive jaw movements evoked by the dopamine D-1/D-2 receptor agonist mixture in a dose-dependent manner. Injection of the non-competitive NMDA receptor antagonist, MK-801 (0.1 and 0.5 mu g/0.2 mu l in each side), into the substantia nigra pars reticulata, which alone did not produce jaw movements, prevented the dopaminergic jaw movements in a dose-dependent manner. Moreover, other behaviors such as grooming, rearing, yawning, vacuous chewing, and locomotor activity that occurred after injections of the dopamine receptor agonist mixture were not significantly altered by the bilateral injections of NMDA or MK-801 into the substantia nigra pars reticulata. Given our previous results showing that both agonist and antagonist of GABA(A) receptors injected into the substantia nigra pars reticulata inhibit the jaw movements elicited by dopamine D-1/D-2 receptor stimulation in the ventrolateral striatum, the present results suggest that there are complex functional interactions between NMDA and GABAA receptors within the substantia nigra pars reticulata that maybe responsible for the common profiles in the affects of NMDA and GABAA receptor agents. (c) 2005 Prous Science. All rights reserved.
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