期刊
ACTA BIOMATERIALIA
卷 1, 期 1, 页码 125-136出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2004.09.006
关键词
conducting polymer; PEDOT; surfactant; microfabricated neural probes; cell adhesion
资金
- NINDS NIH HHS [N01-NS-1-2338] Funding Source: Medline
Ordered conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) was electrochemically fabricated using a self-assembled medium of surfactant molecules as a template. The morphology and microstructure were extensively investigated by optical and electron microscopy, and results show that the coated films were composed of anisotropic domains having a characteristic size of 15-150 nm. The surfactant-templated ordered PEDOT films were electrochemically deposited on microfabricated neural probes with an electrode site area of 1256 mu m(2). The electrical properties were studied by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). EIS showed a lowered magnitude of 35 k Omega (from an initial similar to 800 k Omega) at the biologically relevant frequency of 1 kHz. CV results show that the film has higher charge capacity and is more electrochemically stable than either nodular PEDOT or PPy. Furthermore, we have begun to probe the biological response to such a material intended to define the tissue-material interface. Results show that minute concentrations of the non-ionic surfactant are enough to kill all nearby cells in culture. It is possible however, to create surfactant-templated ordered PEDOT such that SH-SY5Y survive on the conductive polymer. (c) 2004 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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