期刊
ILAR JOURNAL
卷 46, 期 4, 页码 338-345出版社
OXFORD UNIV PRESS
DOI: 10.1093/ilar.46.4.338
关键词
forward genetics; model; mouse; mutation; resource; spontaneous
资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [N01HD053230] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [P30CA034196] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P40RR001183] Funding Source: NIH RePORTER
- NATIONAL EYE INSTITUTE [R01EY007758, R01EY015073] Funding Source: NIH RePORTER
- NCI NIH HHS [CA34196] Funding Source: Medline
- NCRR NIH HHS [P40 RR01183] Funding Source: Medline
- NEI NIH HHS [EY07758, EY015073] Funding Source: Medline
- NICHD NIH HHS [HD53230] Funding Source: Medline
The role of serendipity in science has no better example than the discovery of spontaneous mutations that leads to new mouse models for research. The approach of finding phenotypes and then carrying out genetic analysis is called forward genetics. Serendipity is a key component of discovering and developing mice with spontaneous mutations into animal models of human disease. In this article, the role of serendipity in discovering and developing mouse models is described within a program at The Jackson Laboratory that capitalizes on serendipitous discoveries in large breeding colonies. Also described is how any scientists working with mice can take advantage of serendipitous discoveries as a research strategy to develop new models. Spontaneous mutations cannot be planned but happen in all research mouse colonies and are discovered as unexpected phenotypes. The alert scientist or technician can rationally exploit such chance observations to create new research opportunities.
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