期刊
CARBOHYDRATE RESEARCH
卷 469, 期 -, 页码 55-59出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2018.08.009
关键词
Biomass degradation; Protein engineering; Thermostability
资金
- Danish Ministry of Higher Education and Science through the Instrument Center DANSCATT
- European Community's Seventh Framework Programme (FP7/2007-2013) under BioStruct-X [283570]
- HOPE project (Novo Nordisk Foundation) [NNF17SA0027704]
Lytic polysaccharide monooxygenases (LPMOs) are industrial enzymes which are gaining use in second generation bioethanol production from lignocellulose by acting in synergy with glycoside hydrolases. Here we present the X-ray crystal structure of an AA9 fungal LPMO from Aspergillus fumigants and a variant which has been shown to have better performance at elevated temperatures. Based on the structures, thermal denaturation data and theoretical calculations, we provide a suggestion for the structural basis of the improved stability.
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